金胺O
| 金胺O | |||
|---|---|---|---|
| |||
| |||
| IUPAC名 bis[4-(dimethylamino)phenyl]methaniminium chloride | |||
| 英文名 | Auramine O | ||
| 別名 | 鹼性嫩黃O | ||
| 識別 | |||
| CAS號 | 2465-27-2 
| ||
| PubChem | 17170 | ||
| ChemSpider | 16254 | ||
| SMILES |
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| InChI |
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| InChIKey | JPIYZTWMUGTEHX-UHFFFAOYAY | ||
| 性質 | |||
| 化學式 | C17H22ClN3 | ||
| 摩爾質量 | 303.83 g·mol−1 | ||
| 外觀 | 黃色針狀晶體[1] | ||
| 熔點 | 126 °C（399 K）（[3]） | ||
| 沸點 | 265 °C（538 K）（分解[2]） | ||
| 溶解性（水） | 10 g/L[2] | ||
| 溶解性 | 可溶於乙醇、丙酮[3] | ||
| 危險性 | |||
GHS危險性符號   
| |||
| GHS提示詞 | Danger | ||
| H-術語 | H302, H311, H319, H351, H411 | ||
| P-術語 | P201, P202, P264, P270, P273, P280, P281, P301+312, P302+352, P305+351+338, P308+313, P312, P322, P330 | ||
| NFPA 704 |
 1
3
0
| ||
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |||
金胺O是一種二芳基甲烷螢光染料，常態下為黃色針狀結晶。不易溶於水，易溶於乙醇。它可由4,4'-雙(二甲氨基苯基)甲烷與尿素、氨基磺酸、硫、氨在175 °C下反應而成。[1]
金胺O可用於抗酸細菌（例如Mycobacterium）, 其方法類似抗酸染色法。[4] 也被當做希夫試劑的螢光版來使用。[5]
在金胺-若丹明染色法中與若丹明B一起用來給結核桿菌染色。[6][7]同時也可用作防腐劑。
參考文獻
[編輯]- ^ 1.0 1.1 International Agency for Research on Cancer. Some aromatic amines, organic dyes and related exposures. IARC monographs on the evaluation of carcinogenic risks to humans 99 (Lyon: WHO). 2010. ISBN 978-92-832-1299-7.
- ^ 2.0 2.1 Datenblatt Auramin O [Auramin O安全信息單（MSDS）] (PDF). Herstellers Merck （德語）.
- ^ 3.0 3.1 Gangolli, S. The Dictionary of Substances and Their Effects: A-B. Cambridge, UK: Royal Society of Chemistry. 1999: 402. ISBN 0-85404-808-1. OCLC 41660040.
- ^ Kommareddi S, Abramowsky C, Swinehart G, Hrabak L. Nontuberculous mycobacterial infections: comparison of the fluorescent auramine-O and Ziehl-Neelsen techniques in tissue diagnosis. Hum Pathol. 1984, 15 (11): 1085–9. PMID 6208117. doi:10.1016/S0046-8177(84)80253-1.
- ^ Khavkin T, Kudryavtseva M, Dragunskaya E, Polotsky Y, Kudryavtsev B. Fluorescent PAS-reaction study of the epithelium of normal rabbit ileum and after challenge with enterotoxigenic Escherichia coli. Gastroenterology. 1980, 78 (4): 782–90. PMID 6986320.
- ^ Truant J, Brett W, Thomas W. Fluorescence microscopy of tubercle bacilli stained with auramine and rhodamine. Henry Ford Hosp Med Bull. 1962, 10: 287–96. PMID 13922644.
- ^ Arrowood M, Sterling C. Comparison of conventional staining methods and monoclonal antibody-based methods for Cryptosporidium oocyst detection. J Clin Microbiol. 1989, 27 (7): 1490–5. PMC 267601
. PMID 2475523.
