6-氟色胺

6-氟色胺
临床资料
其他名称	6-Fluorotryptamine; 6-FT; 6-Fluoro-T; PAL-227; PAL227
药物类别	Serotonin receptor agonist; Monoamine releasing agent; Monoamine oxidase inhibitor
识别信息
	IUPAC命名法 2-(6-fluoro-1H-indol-3-yl)ethanamine; ;
CAS号	575-85-9
PubChem CID	854024;
ChemSpider	746410;
ChEMBL	ChEMBL381160;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID60357527 ;
ECHA InfoCard	100.215.037
化学信息
化学式	C10H11FN2
摩尔质量	178.21 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C1=CC2=C(C=C1F)NC=C2CCN;
	InChI InChI=1S/C10H11FN2/c11-8-1-2-9-7(3-4-12)6-13-10(9)5-8/h1-2,5-6,13H,3-4,12H2; Key:BQTOKMYKZPCPRW-UHFFFAOYSA-N;

6-氟色胺（6-FT，6-fluoro-T；代号：PAL-227）是一种5-羟色胺受体激动剂及单胺释放剂，为色胺类化合物。^[1]^[2]

它对血清素 5-HT_1A和5-HT_2A受体具有亲和力，K_i值分别为267 nM和606 nM。^[3]^[4]

参考文献

^ Nakagawasai O, Arai Y, Satoh SE, Satoh N, Neda M, Hozumi M, Oka R, Hiraga H, Tadano T. Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives. Neurotoxicology. January 2004, 25 (1-2): 223–232. PMID 14697897. doi:10.1016/S0161-813X(03)00101-3.
^ Blough BE, Landavazo A, Partilla JS, Decker AM, Page KM, Baumann MH, Rothman RB. Alpha-ethyltryptamines as dual dopamine-serotonin releasers. Bioorg Med Chem Lett. October 2014, 24 (19): 4754–4758. PMC 4211607 . PMID 25193229. doi:10.1016/j.bmcl.2014.07.062.
^ Chen X, Li J, Yu L, Maule F, Chang L, Gallant JA, Press DJ, Raithatha SA, Hagel JM, Facchini PJ. A cane toad (Rhinella marina) N-methyltransferase converts primary indolethylamines to tertiary psychedelic amines. J Biol Chem. October 2023, 299 (10): 105231. PMC 10570959 . PMID 37690691. doi:10.1016/j.jbc.2023.105231.
^ Chen, Xue; Li, Jing; Yu, Lisa; Dhananjaya, D; Maule, Francesca; Cook, Sarah; Chang, Limei; Gallant, Jonathan; Press, David; Bains, Jaideep S; Raithatha, Sheetal; Hagel, Jillian; Facchini, Peter, Bioproduction platform using a novel cane toad (Rhinella marina) N-methyltransferase for psychedelic-inspired drug discovery (PDF), 10 March 2023 [10 March 2025], doi:10.21203/rs.3.rs-2667175/v1