6-氟二甲基色胺

6-氟二甲基色胺
临床资料
其他名称	6-Fluoro-N,N-dimethyltryptamine; 6-Fluoro-DMT; 6-F-DMT; 6F-DMT
药物类别	Serotonin receptor modulator
ATC码	未分配;
识别信息
	IUPAC命名法 2-(6-fluoro-1H-indol-3-yl)-N,N-dimethyl-ethanamine; ;
CAS号	1511-31-5
PubChem CID	121013343;
ChemSpider	26286731 ;
UNII	J4CZH8D9EN;
化学信息
化学式	C12H15FN2
摩尔质量	206.26 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CN(CCC1=CNC2=C1C=CC(F)=C2)C;
	InChI InChI=1S/C12H15FN2/c1-15(2)6-5-9-8-14-12-7-10(13)3-4-11(9)12/h3-4,7-8,14H,5-6H2,1-2H3 ; Key:DZXZPVGWRZCXDH-UHFFFAOYSA-N ;

6-氟二甲基色胺，或称为6-氟-N,N-二甲基色胺（英语：6-Fluoro-N,N-dimethyltryptamine，简称6-fluoro-DMT）是一种含氮有机氟化合物，化学式C
12H
15FN
2，为人工合成的5-羟色胺受体调节剂^[1]^[2]。

参考文献

^ Shulgin AT. Psychotomimetic Agents. Gordon M (编). Psychopharmacological Agents: Use, Misuse and Abuse. Medicinal Chemistry: A Series of Monographs 4. Academic Press. 1976: 59–146. ISBN 978-0-12-290559-9. doi:10.1016/b978-0-12-290559-9.50011-9. This metabolically available site (6 position) was blocked with a fluoro-group in a number of these N,N-dialkyltryptamines. 6-Fluoro-N,N-dimethyltryptamine [(XXXVI), R = CH3] was again found to be less active than the parent N,N-dimethyltryptamine in animal studies (Kalir and Szara, 1966). However, clinical studies with the ethyl homolog [(XXXVI), R = C2H5] has shown that it produces most of the somatic effects of the comparison drug N,N-dipropyltryptamine without any of the psychological changes. It is proposed as an "active placebo" in controlling experiments with possible hallucinogenics (Faillace et al., 1967). The present evidence indicates that chemical substitution on the 6 position of the tryptamine system destroys the psychotomimetic potential of the compound.
^ Ray TS. Psychedelics and the human receptorome. PLOS ONE. February 2010, 5 (2): e9019. Bibcode:2010PLoSO...5.9019R. PMC 2814854 . PMID 20126400. doi:10.1371/journal.pone.0009019 .