6-氟二甲基色胺

6-氟二甲基色胺
臨床資料
其他名稱	6-Fluoro-N,N-dimethyltryptamine; 6-Fluoro-DMT; 6-F-DMT; 6F-DMT
藥物類別	Serotonin receptor modulator
ATC碼	未分配;
識別資訊
	IUPAC命名法 2-(6-fluoro-1H-indol-3-yl)-N,N-dimethyl-ethanamine; ;
CAS號	1511-31-5
PubChem CID	121013343;
ChemSpider	26286731 ;
UNII	J4CZH8D9EN;
化學資訊
化學式	C12H15FN2
摩爾質量	206.26 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CN(CCC1=CNC2=C1C=CC(F)=C2)C;
	InChI InChI=1S/C12H15FN2/c1-15(2)6-5-9-8-14-12-7-10(13)3-4-11(9)12/h3-4,7-8,14H,5-6H2,1-2H3 ; Key:DZXZPVGWRZCXDH-UHFFFAOYSA-N ;

6-氟二甲基色胺，或稱為6-氟-N,N-二甲基色胺（英語：6-Fluoro-N,N-dimethyltryptamine，簡稱6-fluoro-DMT）是一種含氮有機氟化合物，化學式C
12H
15FN
2，為人工合成的5-羥色胺受體調節劑^[1]^[2]。

參考文獻

^ Shulgin AT. Psychotomimetic Agents. Gordon M (編). Psychopharmacological Agents: Use, Misuse and Abuse. Medicinal Chemistry: A Series of Monographs 4. Academic Press. 1976: 59–146. ISBN 978-0-12-290559-9. doi:10.1016/b978-0-12-290559-9.50011-9. This metabolically available site (6 position) was blocked with a fluoro-group in a number of these N,N-dialkyltryptamines. 6-Fluoro-N,N-dimethyltryptamine [(XXXVI), R = CH3] was again found to be less active than the parent N,N-dimethyltryptamine in animal studies (Kalir and Szara, 1966). However, clinical studies with the ethyl homolog [(XXXVI), R = C2H5] has shown that it produces most of the somatic effects of the comparison drug N,N-dipropyltryptamine without any of the psychological changes. It is proposed as an "active placebo" in controlling experiments with possible hallucinogenics (Faillace et al., 1967). The present evidence indicates that chemical substitution on the 6 position of the tryptamine system destroys the psychotomimetic potential of the compound.
^ Ray TS. Psychedelics and the human receptorome. PLOS ONE. February 2010, 5 (2): e9019. Bibcode:2010PLoSO...5.9019R. PMC 2814854 . PMID 20126400. doi:10.1371/journal.pone.0009019 .